Abstract #0729
Multi-shell Diffusion MRI Provides Better Performance in Discriminating Parkinsons Disease
Silvia De Santis 1 , Nicola Toschi 2,3 , Derek K Jones 1 , Claudio Lucetti 4 , Stefano Diciotti 5 , Marco Giannelli 6 , and Carlo Tessa 7
1
CUBRIC Cardiff University, Cardiff, United
Kingdom,
2
Medical
Physics Section, Department of Biomedicine and
Prevention, Faculty of Medicine, University of Rome Tor
Vergata, Italy,
3
Department
of Radiology, A.A. Martinos Center for Biomedical
Imaging, MGH and Harvard Medical School, Boston, MA,
United States,
4
Division
of Neurology Unit, Versilia Hospital, Lido di Camaiore
(Lu), Italy,
5
Department
of Electrical, Electronic, and Information Engineering
Guglielmo Marconi, University of Bologna, Cesena,
Italy,
6
Unit
of Medical Physics, Pisa University Hospital Azienda
Ospedaliero-Universitaria Pisana, Pisa, Italy,
7
Division
of Radiology Unit, Versilia Hospital, Lido di Camaiore
(Lu), Italy
Parkinson's disease (PD) is associated with the death of
dopamine-generating cells in the substantia nigra. We
apply the composite hindered and restricted model of
diffusion (CHARMED) and the stretched exponential model
(SEM) to test the ability of multi-shell methods to
differentiate between Parkinson's Disease (PD) patients
and healthy controls. We found that multi-shell
diffusion MRI provides significantly higher sensitivity
and specificity to microstructural WM alterations in PD
when compared to conventional DTI. Employing more
advanced models such as CHARMED or SEM to study
neurodegenerative pathologies may aid the interpretation
of otherwise aspecific differences which can be detected
with DTI.
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