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Abstract #0730

In-vivo measurements of axon density and axon diameter in the Corpus Callosum in Multiple Sclerosis

Torben Schneider 1 , Wallace Brownlee 1 , Jonathan Clayden 2 , Olga Ciccarelli 3 , David H Miller 1 , Daniel C Alexander 4 , and Claudia A M Wheeler-Kingshott 1

1 NMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, London, United Kingdom, 2 UCL Institute of Child Health, Imaging & Biophysics Unit, London, United Kingdom, 3 Brain Repair & Rehabilitation, UCL Institute of Neurology, London, United Kingdom, 4 Centre of Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom

It is known that microstructural changes in the Corpus Callosum are associated with disability in Multiple Sclerosis. Here, we have used a novel diffusion MRI protocol and analysis method to measure axon density and diameter in the Corpus Callosum in MS in-vivo and on a standard clinical scanner. Our preliminary results suggest a regional decrease of axon density and increase in axon diameter both in normal appearing white matter and lesion tissue, which is consistent with findings from ex vivo histology.

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