Abstract #0730
In-vivo measurements of axon density and axon diameter in the Corpus Callosum in Multiple Sclerosis
Torben Schneider 1 , Wallace Brownlee 1 , Jonathan Clayden 2 , Olga Ciccarelli 3 , David H Miller 1 , Daniel C Alexander 4 , and Claudia A M Wheeler-Kingshott 1
1
NMR Research Unit, Department of
Neuroinflammation, Queen Square MS Centre, UCL Institute
of Neurology, London, United Kingdom,
2
UCL
Institute of Child Health, Imaging & Biophysics Unit,
London, United Kingdom,
3
Brain
Repair & Rehabilitation, UCL Institute of Neurology,
London, United Kingdom,
4
Centre of Medical
Image Computing, Department of Computer Science,
University College London, London, United Kingdom
It is known that microstructural changes in the Corpus
Callosum are associated with disability in Multiple
Sclerosis. Here, we have used a novel diffusion MRI
protocol and analysis method to measure axon density and
diameter in the Corpus Callosum in MS in-vivo and on a
standard clinical scanner. Our preliminary results
suggest a regional decrease of axon density and increase
in axon diameter both in normal appearing white matter
and lesion tissue, which is consistent with findings
from ex vivo histology.
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