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Abstract #0731

Utility of MR-Spectroscopy in early drug discovery: characterization of dynamic temporal metabolic changes following psychoactive challenges in the rodent brain

Sakthivel Sekar 1 , Sankar Seramani 1 , Joanne Garnell 1 , and Kishore Kumar Bhakoo 1

1 Translational Imaging Industrial Lab, Singapore Bioimaging Consortium, Biopolis, Singapore

Our findings exemplify the utility of 1H-MRS in early drug discovery, to non-invasively investigate the dynamic metabolite temporal changes in the brain, to further understand (or corroborate) the behavioral effects of psychoactive compounds [Sekar et al., 2013] and their functional activation(s) observed with other Neuroimaging modalities (fMRI, rs-fMRI, electrophysiology, etc) [Sekar et al., 2010, 2011, 2013]

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