Abstract #0734
Restoration of Abnormal Interconnectivity between Memory and Emotional Processing Circuits in Remitted Late-Life Depression
Wenjun Li 1 , B. Douglas Ward 2 , Gang Chen 2 , Xiaolin Liu 2 , Jennifer Jones 3 , Piero Antuono 3 , Shi-Jiang Li 1,2 , and Joseph Goveas 1
1
Psychiatry and Behavioral Medicine, Medical
College of Wisconsin, Milwaukee, WI, United States,
2
Biophysics,
Medical College of Wisconsin, WI, United States,
3
Neurology,
Medical College of Wisconsin, WI, United States
Although task-based functional MRI and single-seed
functional connectivity MRI have been extensively used
to study the disease, these methods show limited success
in simultaneously analyzing multiple brain circuits. In
current study, we use a recently developed method called
step-wise connectivity to identify the brain regions
that are responsible for the integration of memory
encoding and emotional processing networks. We
hypothesize abnormal interconnectivity between memory
and emotional processing networks that will be seen in
LLD will show recovery towards normal patterns remitted
patients.
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