Meeting Banner
Abstract #0734

Restoration of Abnormal Interconnectivity between Memory and Emotional Processing Circuits in Remitted Late-Life Depression

Wenjun Li 1 , B. Douglas Ward 2 , Gang Chen 2 , Xiaolin Liu 2 , Jennifer Jones 3 , Piero Antuono 3 , Shi-Jiang Li 1,2 , and Joseph Goveas 1

1 Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, WI, United States, 2 Biophysics, Medical College of Wisconsin, WI, United States, 3 Neurology, Medical College of Wisconsin, WI, United States

Although task-based functional MRI and single-seed functional connectivity MRI have been extensively used to study the disease, these methods show limited success in simultaneously analyzing multiple brain circuits. In current study, we use a recently developed method called step-wise connectivity to identify the brain regions that are responsible for the integration of memory encoding and emotional processing networks. We hypothesize abnormal interconnectivity between memory and emotional processing networks that will be seen in LLD will show recovery towards normal patterns remitted patients.

This abstract and the presentation materials are available to members only; a login is required.

Join Here