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Abstract #0735

Lithium brain absorption in the elderly versus younger patients with bipolar disease.

Maria Otaduy 1 , Ivan Aprahaiam 2 , Rodolfo Ladeira 2 , Rodrigo Machado-Vieira 3,4 , Claudia Leite 5 , Wagner Gattaz 6 , and Orestes Forlenza 2

1 Laboratory of Magnetic Resonance in Neuroradiology, LIM 44, Institute and Department of Radiology, University of So Paulo, So Paulo, So Paulo, Brazil, 2 Laboratory of Neuroscience, LIM 27, Institute and Department of Psychiatry, University of So Paulo, So Paulo, So Paulo, Brazil, 3 Laboratory of Neuroscience, LIM 27, Institute and Department of Psychiatry, University of So Paulo, So Paulo, Brazil, 4 Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States, 5 Laboratory of Magnetic Resonance in Neuroradiology, LIM 44, Institute and Department of Radiology, University of So Paulo, Sao Paulo, Brazil, 6 Laboratory of Neuroscience, LIM 27, Institute and Department of Psychiatry, University of So Paulo, So Paulo, Sao Paulo, Brazil

In this study we used 7Li-MRS to quantify brain lithium concentration in patients with bipolar disease under lithium treatment. The purpose of this study was to evaluate if lithium brain absorption is different in young (20-40yrs) from elderly (60-80yrs) patients. For that we evaluated the mean brain to plasma lithium ratio for both groups and found it to be the same. Noteworthy, within the younger group we found a negative correlation between brain to plasma lithium ratio and age that was not observed for the elderly group.

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