Abstract #0736
The Impact of Ebselen Administration on Brain myo-Inositol Concentration
Uzay E Emir 1 , Nisha Singh 2,3 , Ann Sharpley 3 , Charles Masaki 3 , Sridhar Vasudevan 2 , Peter Jezzard 1 , Phil Cowen 3 , and Grant Churchill 2
1
University of Oxford, FMRIB Centre, Oxford,
Oxfordshire, United Kingdom,
2
University
of Oxford, Department of Pharmacology, Oxford,
Oxfordshire, United Kingdom,
3
University
of Oxford, Department of Psychiatry, Oxford,
Oxfordshire, United Kingdom
Bipolar disorder (BPD) is a relatively common
psychiatric disorder for which lithium is the gold
standard of treatment but it has a number of
side-effects which require careful monitoring of plasma
levels of the drug. A drug, ebselen, that mimics the
effect of lithium but without its side-effects has been
recently reported. In this study, we assessed if ebselen
reduces brain inositol levels, compared to placebo using
magnetic resonance spectroscopy.
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