Ketamine Improves Astroglial Metabolic Activity and Neurotransmission in Social Defeat Model of Depression: A 1 H-[ 13 C]-NMR Study

Astroglia play a major role in recycling and metabolism of neurotransmitters at synapse. The functional characteristics of astroglia is not well understood in depression. Ketamine has been reported to possess rapid anti-depressant activity. The objective of the current study was to evaluate the astroglial metabolic activity, and effects of ketamine in social defeat model of depression. Depression led to reduction in the astroglial metabolic activity. Moreover, sub-anesthetic dose of ketamine was able to restore behavioral phenotypes and astroglial activity in depressed mice.

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