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Abstract #0738

Electroconvulsive Therapy (ECT) induced neurochemical modulation as measured by 1 HMRS in Major Depression

Shantanu H Joshi 1 , Stephanie Njau 1 , Amber Leaver 1 , Antonio Marquina 2 , Roger P Woods 1 , Randall Espinoza 3 , and Katherine L Narr 1

1 Neurology, UCLA, Los Angeles, CA, United States, 2 Mathematics, University of Valencia, Valencia, Spain, 3 Psychiatry and Behavioral Sciences, UCLA, Los Angeles, CA, United States

Proton magnetic resonance spectroscopy (1HMRS) offers a non-invasive technique for measuring the neurochemical disturbances in cortico-limbic regulatory circuits in depression. Electroconvulsive therapy (ECT) is a rapidly acting treatment for patients with severe depression. While patients with major depression show abnormal neurochemistry, several emerging hypotheses for ECT induced neuroplasticity have led to measuring the ECT driven neuro-metabolite response using 1HMRS. Here, we examined cross-sectional and longitudinal ECT treatment effects on glutamate/glutamine (Glx), N-acetyl aspartate (NAA), creatinine+phospocreatinie (Cr/PCr), and myo-inositol (mI) in the hippocampus, and the dorsal and subgenual cingulate in patients with major depressive disorder (MDD) along with cross-sectional diagnosis effects in metabolites when compared to age and gender matched healthy controls.

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