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Abstract #0744

Skeletal muscle tissue characterization by 23 Na NMRS under different vascular filling conditions

Benjamin Marty 1,2 , Teresa Gerhalter 1,2 , Ericky C.A. Araujo 1,2 , Eric Giacomini 3 , and Pierre G. Carlier 1,2

1 NMR laboratory, Institute of Myology, Paris, France, 2 NMR laboratory, CEA/I2BM/MIRCen, Paris, France, 3 UNIRS, CEA/I2BM/NeuroSpin, Gif-Sur-Yvette, France

The sodium ion is involved in a vast number of functions at the cellular level. Changes in sodium intracellular concentration or volume fraction indicate disorders that alter cell function/integrity or that are responsible for metabolic changes. Inversion-recovery and triple quantum filtration (TQF) methods have been previously proposed to discriminate intra- and extracellular Na+ signals. Here, we proposed a 23 Na MRS protocol to characterize skeletal muscle tissues in reasonable acquisition times and evaluated the sensitivity of different parameters (FID signal, TQF signal, TQF/FID ratio, T1 value, short T2* fraction) to differentiate various intracellular volume fractions conditions.

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