Abstract #0745
Activation of Skeletal Muscle PDH with DCA Increases Steady State ΔGATP Below The Aerobic Threshold
Jonathan David Kasper 1 , Anne Tonson 1 , Mike Klingler 1 , Joshua Hubert 1 , Ronald Meyer 2 , and Robert Wiseman 2
1
Physiology, Michigan State University, East
Lansing, Michigan, United States,
2
Physiology
and Radiology, Michigan State University, East Lansing,
Michigan, United States
Skeletal muscle is a thermodynamic system and its
energetic state is determined by the magnitude of the
mitochondrial redox, proton motive force, and ΔGATP
potentials. Pyruvate dehydrogenase (PDH) flux is
directly linked to NADH production and influences
mitochondrial redox potential. This study sought to
evaluate the effect of PDH activation on muscle
energetics. Pharmacological activation of PDH results in
elevation of steady state ΔGATP at rest and during
stimulation below the aerobic threshold of muscle
contraction. This effect is attributed to elevation of
steady state redox potential and implicates PDH as an
important site of regulation for skeletal muscle
energetics.
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