Abstract #0746
Assessment of thigh muscle in healthy controls and dermatomyositis patients with diffusion tensor imaging, intravoxel incoherent motion, and dynamical DTI
Eric Edward Sigmund 1,2 , Steven H. Baete 1,2 , Thomas Luo 2 , Karan Patel 2 , Mary Bruno 1,2 , David Mossa 1,2 , David Stoffel 1,2 , Alisa Femia 3 , Sarika Ramachandran 3 , Andrew Franks 3 , and Jenny Bencardino 4
1
Center for Advanced Imaging Innovation and
Research (CAI2R), Department of Radiology, NYU School of
Medicine, NY, NY, United States,
2
Bernard
and Irene Schwartz Center for Biomedical Imaging,
Department of Radiology, NYU School of Medicine, NY, NY,
United States,
3
Department
of Dermatology, NYU School of Medicine, NY, NY, United
States,
4
Department
of Radiology, NYU School of Medicine, NY, NY, United
States
Dermatomyositis (DM) is a degenerative condition needing
diagnostic/prognostic biomarkers, which diffusion
imaging may provide. We collected anatomic, Dixon, and
static diffusion imaging (DTI, IVIM) at rest, and
dynamic DTI (MEDITATE) before and after leg-lift
exercise, in thigh muscles of DM patients and controls
at 3 T. Static imaging reveals higher fat fraction in
patients than controls, and in hamstrings, elevated
diffusion metrics in patients vs. controls; however,
regional heterogeneity exists. Dynamic imaging shows
significantly larger exercise response of radial
diffusion in patients than controls, with slower return
to equilibrium. These markers may enhance diagnosis and
predict treatment response in DM.
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