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Abstract #0747

T 2 and T 1ρ detect early regenerative changes in ischemic skeletal muscle

Hanne Hakkarainen 1 , Galina Wirth 1 , Petra Korpisalo-Pirinen 1 , Seppo Yl-Herttuala 1 , and Timo Liimatainen 1,2

1 University of Eastern Finland, A.I. Virtanen Institute for Molecular Sciences, Kuopio, Finland, 2 Imaging Center, Kuopio University Hospital, Kuopio, Finland

T 2 and T relaxation time constants were applied to differentiate areas of early regeneration in a mouse hind limb ischemia model. Percentages of areas having early signs of regeneration and areas of other tissue morphologies were determined based on T 2 and T of the ischemic muscle cross section and correlations between histology derived percentages were calculated. Both T 2 and T were able to detect the early regenerative areas making them potential markers of activation of regeneration of skeletal muscle tissue after ischemia.

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