Abstract #0747
T 2 and T 1ρ detect early regenerative changes in ischemic skeletal muscle
Hanne Hakkarainen 1 , Galina Wirth 1 , Petra Korpisalo-Pirinen 1 , Seppo Yl-Herttuala 1 , and Timo Liimatainen 1,2
1
University of Eastern Finland, A.I. Virtanen
Institute for Molecular Sciences, Kuopio, Finland,
2
Imaging
Center, Kuopio University Hospital, Kuopio, Finland
T
2
and
T
1ρ
relaxation
time constants were applied to differentiate areas of
early regeneration in a mouse hind limb ischemia model.
Percentages of areas having early signs of regeneration
and areas of other tissue morphologies were determined
based on T
2
and
T
1ρ
of
the ischemic muscle cross section and correlations
between histology derived percentages were calculated.
Both T
2
and
T
1ρ
were
able to detect the early regenerative areas making them
potential markers of activation of regeneration of
skeletal muscle tissue after ischemia.
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