Reproducibility and sensitivity of muscle-water T2 determined independently of fat fraction with IDEAL-CPMG
Christopher D J Sinclair 1 , Jasper M Morrow 1 , Robert L Janiczek 2 , Matthew R M Evans 1 , Elham Rawah 1 , Sachit Shah 1 , Michael G Hanna 1 , Mary M Reilly 1 , Tarek A Yousry 1 , and John S Thornton 1
Institute of Neurology, University College
London, London, London, United Kingdom,
Medicine Imaging, GlaxoSmithKline, Uxbridge, Middlesex,
Measuring muscle-water T2 (T2w) independently of fat is
increasingly important for detecting potentially
reversible disease changes in imminent clinical trials.
The IDEAL-CPMG sequence combines chemical-shift
fat-fraction (f.f.) quantification with spin-echo T2
relaxometry in a single acquisition to determine T2w.
Here we measured the scan-rescan reproducibility of
IDEAL-CPMG T2w and f.f. in healthy individuals and
applied it in a group of neuromuscular patients with
periodic paralysis to determine the association between
T2w and f.f.. Reproducibility was excellent and
IDEAL-CPMG was sensitive to subtle T2w changes. There
was a weak association between T2w and f.f., likely
reflecting concurrent water and fat pathologies in this
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