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Abstract #0748

Reproducibility and sensitivity of muscle-water T2 determined independently of fat fraction with IDEAL-CPMG

Christopher D J Sinclair 1 , Jasper M Morrow 1 , Robert L Janiczek 2 , Matthew R M Evans 1 , Elham Rawah 1 , Sachit Shah 1 , Michael G Hanna 1 , Mary M Reilly 1 , Tarek A Yousry 1 , and John S Thornton 1

1 Institute of Neurology, University College London, London, London, United Kingdom, 2 Experimental Medicine Imaging, GlaxoSmithKline, Uxbridge, Middlesex, United Kingdom

Measuring muscle-water T2 (T2w) independently of fat is increasingly important for detecting potentially reversible disease changes in imminent clinical trials. The IDEAL-CPMG sequence combines chemical-shift fat-fraction (f.f.) quantification with spin-echo T2 relaxometry in a single acquisition to determine T2w. Here we measured the scan-rescan reproducibility of IDEAL-CPMG T2w and f.f. in healthy individuals and applied it in a group of neuromuscular patients with periodic paralysis to determine the association between T2w and f.f.. Reproducibility was excellent and IDEAL-CPMG was sensitive to subtle T2w changes. There was a weak association between T2w and f.f., likely reflecting concurrent water and fat pathologies in this patient group.

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