In vivo 37 Cl MRI of Human Calf Muscle at 7T

Chloride (Cl ^- ) plays an important role in several physiological processes. However, due to the very short transverse relaxation times, quantitative measurements of ³⁵ Cl are challenging. Although this isotope exhibits higher NMR sensitivity than ³⁷ Cl, the 1.27-fold lower electrical quadrupole moment of ³⁷ Cl results in longer relaxation times and could offer an imaging advantage over ³⁵ Cl. To prove this effect a quadrature birdcage coil for ³⁷ Cl MRI was built and used for in vivo and phantom measurements. This work shows the first ³⁷ Cl in vivo images of a human calf muscle. For comparison of relaxation times, ³⁵ Cl MRI was also performed.

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