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Abstract #0760

Ultra-short T E STEAM improves hepatic lipid quantification and profiling at 7T

Martin Gajdok 1 , Grzegorz Chadzynski 2,3 , Vladimr Mlynrik 1 , Marek Chmelk 1 , Wolfgang Bogner 1 , Ladislav Valkovic 1,4 , Ivica Just Kukurov 1 , Siegfried Trattnig 1 , and Martin Krk 1,5

1 MRCE, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2 Department of Biomedical Magnetic Resonance, University of Tbingen, Tbingen, Germany, 3 Department of High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tbingen, Germany, 4 Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, 5 Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria

Previous 1 H MRS measurements in the brain have demonstrated advantages of ultra-short T E at ultra-high fields. Besides higher SNR, T 2 relaxation and J-modulation effects in the spectra can be minimized. This is of particular importance in the liver tissue, where both effects along with iron deposition have to be taken into account. The STEAM with T E =6ms provided higher SNR and reproducibility for precise estimation of HCL. Furthermore the high spectral resolution at 7T with sufficient CRLBs of single lipid resonances highlights the potential of this sequence to be used in advanced studies of hepatic lipid profiles in vivo .

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