Ultra-high field in vivo localized two dimensional correlated MR spectroscopy to probe membrane degradation during progression of Alzheimers disease

In this work we present the first in vivo localized two dimension spectroscopy to unambiguously identify glycerophospholipids (GPC) and phosphocholine (PC) in cortex/hippocampus region of mouse brain at 9.4T. The increase in GPC is an indicator of increased breakdown of phospholipids in Alzheimers disease. Till now the detection of phosphocholine and GPC in disease affected regions in AD brain has not been possible due to lack of sensitive detection methods. In the same brain region we visualized amyloid beta plaques by in vivo MRI. Our results show a clear correlation between plaque deposition and membrane breakdown in AD mouse brain.

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