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Abstract #0769

The evaluation of the white matter development and small-world networks in the fetal brain MRI using sBTFE sequence

Bing Zhang # 1 , Chenchen Yan # 1 , Ming Li 1 , Huiting Wang 1 , Zuzana Nedelska 2 , Tong Ru 3 , Zhiqun Wang 3 , Jie Li 3 , Jian Yang 4 , Yali Hu* 3 , and Bin Zhu* 1

1 Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, 2 Memory Disorders Clinic,Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Czech Republic, 3 Department of Gynaecology and Obstetrics, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, 4 Department of Radiology, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China

We aimed to examine the white matter development and small-world networks in 150 fetal brains across the different gestational weeks using sBTFE on MRI. The bilateral prefrontal signal intensity during gestational week 21-23 was lower than other subplate zones, consistent with the germinal matrix being present that region at that time. The lower degree of the connection pattern in brain at gestational week 25 could be due to the unsynchronized cellular migration within brain regions. And the similar pattern of the small-world properties between gestational weeks 28 and 33-39 indicated the fetal brain was maturating after gestational week 28.

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