Abstract #0770
Disrupted developmental organization of brain connectivity in fetuses with corpus callosum agenesis: an in utero study
Andrs Jakab 1 , Gregor Kasprian 2 , Ernst Schwartz 2 , Veronika Schpf 3 , Daniela Prayer 2 , and Georg Langs 1,4
1
CIR Lab, Department of Biomedical Imaging
and Image-guided Therapy, Medical University of Vienna,
Vienna, Austria,
2
Department
of Biomedical Imaging and Image-guided Therapy, Medical
University of Vienna, Vienna, Austria,
3
Institute
for Psychology, University of Graz, Graz, Austria,
4
Computer
Science and Artificial Intelligence Lab, Massachusetts
Institute of Technology, Cambridge, MA, United States
We utilized prenatal diffusion tensor imaging to map the
globally altered structural brain connectivity in second
and third trimester fetuses with corpus callosum
agenesis. We have shown by connectome-level tractography
that callosal agenesis manifests in excessive structural
connectivity, which constantly intensifies during
gestation. Our results indicate that misguided axons
form aberrant antero-posteriorly running pathways not
only adjacent to the median surface of the hemispheres,
but distributed across the lateral parts of the
convexity.
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