Assessing brain damage after perinatal hypoxic-ischaemia using an automated protocol for combined regional analysis of the Cerebral Blood Flow and MR spectroscopy
Magdalena Sokolska 1 , Cristina Uria-Avellanal 2 , M. Jorge Cardoso 3 , Maa Proisy 2 , Alan Bainbridge 4 , Sebastien Ourselin 3 , David Thomas 1 , Nicola Robertson 2 , and Xavier Golay 1
UCL Institute of Neurology, London, United
Institute for Women's Health, United Kingdom,
for Medical Image Computing, UCL, United Kingdom,
Medical Physics and Bioengineering, United Kingdom
Perinatal hypoxia-ischemia (HI) can cause catastrophic
alteration of brain metabolism and physiology, resulting
in neonatal encephalopathy. Metabolic changes detected
using magnetic resonance spectroscopy (MRS) have been
used as a reliable predictor of clinical outcome.
Abnormalities in cerebral blood flow (CBF), reflecting
cerebral physiology, have also been linked to HI. The
aim of this study was to develop an automated framework
for regional analysis of CBF and to investigate the
added value of combining thalamic MRS with detailed
regional CBF analysis for the inclusion of ASL as a
potential biomarker of outcome in HIE.
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