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Abstract #0772

Assessing brain damage after perinatal hypoxic-ischaemia using an automated protocol for combined regional analysis of the Cerebral Blood Flow and MR spectroscopy

Magdalena Sokolska 1 , Cristina Uria-Avellanal 2 , M. Jorge Cardoso 3 , Maa Proisy 2 , Alan Bainbridge 4 , Sebastien Ourselin 3 , David Thomas 1 , Nicola Robertson 2 , and Xavier Golay 1

1 UCL Institute of Neurology, London, United Kingdom, 2 UCL Institute for Women's Health, United Kingdom, 3 Centre for Medical Image Computing, UCL, United Kingdom, 4 UCH Medical Physics and Bioengineering, United Kingdom

Perinatal hypoxia-ischemia (HI) can cause catastrophic alteration of brain metabolism and physiology, resulting in neonatal encephalopathy. Metabolic changes detected using magnetic resonance spectroscopy (MRS) have been used as a reliable predictor of clinical outcome. Abnormalities in cerebral blood flow (CBF), reflecting cerebral physiology, have also been linked to HI. The aim of this study was to develop an automated framework for regional analysis of CBF and to investigate the added value of combining thalamic MRS with detailed regional CBF analysis for the inclusion of ASL as a potential biomarker of outcome in HIE.

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