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Abstract #0773

Basal ganglia and thalamic volumes with motor and cognitive outcomes in very preterm 7 year old children.

Wai Yen Loh 1,2 , Deanne K Thompson 1,2 , Jeanie LY Cheong 1,3 , Alicia J Spittle 1,3 , Jian Chen 1,4 , Katherine J Lee 1,3 , Terrie E Inder 5 , Alan Connelly 2,3 , Lex W Doyle 1,3 , and Peter J Anderson 1,3

1 Murdoch Childrens Research Institute, Melbourne, Victoria, Australia, 2 Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia, 3 University of Melbourne, Melbourne, Victoria, Australia, 4 Monash University, Melbourne, Victoria, Australia, 5 Brigham and Women's Hospital, Boston, Massachusetts, United States

Very preterm survivors (born <32 weeks gestation) experience motor and cognitive impairments. The basal ganglia and thalamus are key relay structures within the brain that modulate motor control and cognition. This study segmented the basal ganglia (accumbens, caudate, pallidum and putamen) and thalamus in 154 very preterm and 36 term children at age 7 years, using T1 images. Very preterm children had reduced pallidal and thalamic volumes compared with controls. Volumes in several of these relay structures were associated with motor function and IQ in very preterm children. This study contributes towards understanding the underlying motor and cognitive deficits observed in very preterm children.

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