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Abstract #0777

Brain connectomics and social cognition from infancy to early adolescence: effects of IUGR

Emma Muoz-Moreno 1 , Elda Fischi-Gomez 2,3 , Dafnis Batalle 4 , Lana Vasung 3 , Morgane Reveillon 3 , Cristina Borradori-Tolsa 3 , Elisenda Eixarch 4,5 , Jean-Philippe Thiran 2,6 , Eduard Gratacos 4,5 , and Petra Susan Hppi 3

1 Fetal and Perinatal Medicine Research Group, IDIBAPS, Barcelona, Barcelona, Spain, 2 Ecole Polytecnique Fdrale de Laussane, Signal Processing Laboratory 5 (LTS5), Laussane, Switzerland, 3 Division of Development and Growth, Department of Pediatrics, University of Geneva, Geneva, Switzerland, 4 Fetal and Perinatal Medicine Research Group, IDIBAPS, Barcelona, Spain, 5 Maternal-Fetal Medicine Department, ICGON, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain, 6 Department of Radiology, University Hospital Center (CHUV) and University of Lausanne (UNIL), Laussane, Switzerland

Perinatal conditions, such as prematurity and intrauterine growth restriction (IUGR), altering normal brain development can have consequences in short- and long-term brain structure and function. Changes in brain connectivity associated to IUGR have been already described by connectomics. In this work, we use connectomics to analyse how brain network organization at 1-, 6- and 10-year-old children with and without IUGR correlates with their performance in neuropsychological tests. Results show a higher risk of social cognitive disorders, related to hyperactivity and altered executive function, in IUGR children, and a strong correlation between brain network metrics and neurodevelopmental evaluation.

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