Abstract #0777
Brain connectomics and social cognition from infancy to early adolescence: effects of IUGR
Emma Muoz-Moreno 1 , Elda Fischi-Gomez 2,3 , Dafnis Batalle 4 , Lana Vasung 3 , Morgane Reveillon 3 , Cristina Borradori-Tolsa 3 , Elisenda Eixarch 4,5 , Jean-Philippe Thiran 2,6 , Eduard Gratacos 4,5 , and Petra Susan Hppi 3
1
Fetal and Perinatal Medicine Research Group,
IDIBAPS, Barcelona, Barcelona, Spain,
2
Ecole
Polytecnique Fdrale de Laussane, Signal Processing
Laboratory 5 (LTS5), Laussane, Switzerland,
3
Division
of Development and Growth, Department of Pediatrics,
University of Geneva, Geneva, Switzerland,
4
Fetal
and Perinatal Medicine Research Group, IDIBAPS,
Barcelona, Spain,
5
Maternal-Fetal
Medicine Department, ICGON, Hospital Clinic, Universitat
de Barcelona, Barcelona, Spain,
6
Department
of Radiology, University Hospital Center (CHUV) and
University of Lausanne (UNIL), Laussane, Switzerland
Perinatal conditions, such as prematurity and
intrauterine growth restriction (IUGR), altering normal
brain development can have consequences in short- and
long-term brain structure and function. Changes in brain
connectivity associated to IUGR have been already
described by connectomics. In this work, we use
connectomics to analyse how brain network organization
at 1-, 6- and 10-year-old children with and without IUGR
correlates with their performance in neuropsychological
tests. Results show a higher risk of social cognitive
disorders, related to hyperactivity and altered
executive function, in IUGR children, and a strong
correlation between brain network metrics and
neurodevelopmental evaluation.
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