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Abstract #0778

Comparison of CBF measured with velocity selective ASL and pulsed ASL in pediatric patients with prolonged arterial transit times due to Moymoya Disease

Divya S Bolar 1,2 , Borjan Gagoski 3 , Richard L Robertson 4 , Elfar Adalsteinsson 5 , Bruce R Rosen 1,2 , and P Ellen Grant 3

1 Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, 2 MGH/HST Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 3 Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, MA, United States, 4 Department of Radiology, Boston Children's Hospital, MA, United States, 5 Department of Electrical Engineering & Computer Science, Massachusetts Institute of Technology, MA, United States

Imaging cerebral blood flow (CBF) with traditional arterial spin labeling (ASL) is limited in diseases with delayed arterial transit such as ischemic stroke and moyamoya disease, resulting in large-vessel artifacts and perfusion underestimation. Velocity-selective ASL (VSASL) has been introduced to improve CBF quantification in these cases and is theoretically insensitive to arterial transit times. In this study, VSASL and traditional pulsed ASL were used to assess CBF in pediatric moyamoya patients. Results demonstrate that PASL is severely affected by delayed arterial transit, resulting in macrovascular artifact and perfusion defects, while VSASL appears unaffected, yielding expected microvascular perfusion. Angiographic data correlate these findings.

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