Abstract #0778
Comparison of CBF measured with velocity selective ASL and pulsed ASL in pediatric patients with prolonged arterial transit times due to Moymoya Disease
Divya S Bolar 1,2 , Borjan Gagoski 3 , Richard L Robertson 4 , Elfar Adalsteinsson 5 , Bruce R Rosen 1,2 , and P Ellen Grant 3
1
Department of Radiology, Massachusetts
General Hospital, Boston, MA, United States,
2
MGH/HST
Martinos Center for Biomedical Imaging, Charlestown, MA,
United States,
3
Fetal
Neonatal Neuroimaging and Developmental Science Center,
Boston Children's Hospital, MA, United States,
4
Department
of Radiology, Boston Children's Hospital, MA, United
States,
5
Department
of Electrical Engineering & Computer Science,
Massachusetts Institute of Technology, MA, United States
Imaging cerebral blood flow (CBF) with traditional
arterial spin labeling (ASL) is limited in diseases with
delayed arterial transit such as ischemic stroke and
moyamoya disease, resulting in large-vessel artifacts
and perfusion underestimation. Velocity-selective ASL
(VSASL) has been introduced to improve CBF
quantification in these cases and is theoretically
insensitive to arterial transit times. In this study,
VSASL and traditional pulsed ASL were used to assess CBF
in pediatric moyamoya patients. Results demonstrate that
PASL is severely affected by delayed arterial transit,
resulting in macrovascular artifact and perfusion
defects, while VSASL appears unaffected, yielding
expected microvascular perfusion. Angiographic data
correlate these findings.
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