Abstract #0779
Highly-accelerated chemical exchange saturation transfer (CEST) measurements with linear algebraic modeling (SLAM)
Yi Zhang 1 , Hye-Young Heo 1 , Dong-Hoon Lee 1 , Shanshan Jiang 1 , Paul Bottomley 1 , and Jinyuan Zhou 1,2
1
Division of MR Research, Department of
Radiolgoy, Johns Hopkins University, Baltimore,
Maryland, United States,
2
F.
M. Kirby Research Center for Functional Brain Imaging,
Kennedy Krieger Institute, Baltimore, Maryland, United
States
Voxel-by-voxel CEST maps provide in vivo molecular level
information that can have clinical value. However, for
quantitative measures, regional average CEST
measurements routinely suffice for diagnosis and or
assessing treatment. A recently-developed
methodspectroscopy with linear algebraic modeling or
SLAMcan directly provide compartmental measurements,
while offering a dramatic reduction in scan times by
dropping low-SNR, high k-space phase-encoding steps
depending on the number of compartments. Here, SLAM is
adapted to CEST acquisitions from brain tumor studies,
and shown to yield quantitatively equivalent results to
standard CEST, with acceleration factors of up to
45-fold.
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