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Abstract #0779

Highly-accelerated chemical exchange saturation transfer (CEST) measurements with linear algebraic modeling (SLAM)

Yi Zhang 1 , Hye-Young Heo 1 , Dong-Hoon Lee 1 , Shanshan Jiang 1 , Paul Bottomley 1 , and Jinyuan Zhou 1,2

1 Division of MR Research, Department of Radiolgoy, Johns Hopkins University, Baltimore, Maryland, United States, 2 F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, United States

Voxel-by-voxel CEST maps provide in vivo molecular level information that can have clinical value. However, for quantitative measures, regional average CEST measurements routinely suffice for diagnosis and or assessing treatment. A recently-developed methodspectroscopy with linear algebraic modeling or SLAMcan directly provide compartmental measurements, while offering a dramatic reduction in scan times by dropping low-SNR, high k-space phase-encoding steps depending on the number of compartments. Here, SLAM is adapted to CEST acquisitions from brain tumor studies, and shown to yield quantitatively equivalent results to standard CEST, with acceleration factors of up to 45-fold.

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