Abstract #0781
Monitoring therapeutic response on non-small cell lung cancer in chemotherapy by amide proton transfer (APT) imaging in mice
Keisuke Ishimatsu 1 , Shanrong Zhang 1 , Koji Sagiyama 1 , Osamu Togao 1 , Brenda Timmons 2 , John Minna 2 , and Masaya Takahashi 1
1
Advanced Imaging Research Center, University
of Texas Southwestern Medical Center, Dallas, Texas,
United States,
2
Hamon
Center for Therapeutic Oncology, Internal Medicine,
University of Texas Southwestern Medical Center, Dallas,
Texas, United States
The objective of our study is to investigate whether
amide proton transfer (APT) imaging can be used for
monitoring treatment responses of the lung cancer in
chemotherapy. We compared temporal changes of APT signal
in a non-small cell lung carcinoma with and without
erlotinib which is a small molecule epidermal growth
factor receptor tyrosine kinase inhibitor in mice.
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