Abstract #0782
Dynamic Imaging of D-Glucose at 7T: First Experiments in Human Brain
Xiang Xu 1,2 , Craig K. Jones 1,2 , Nirbhay N. Yadav 1,2 , Linda Knutsson 3 , Jun Hua 1,2 , Rita Kalyani 4 , Erica Hall 4 , John Laterra 5 , Jaishri Blakeley 5 , Roy Strowd 5 , Prakash Ambady 5 , Martin Pomper 1 , Peter Barker 1,2 , Guanshu Liu 1,2 , Kannie W.Y. Chan 1,2 , Michael T. McMahon 1,2 , Robert D. Stevens 5,6 , and Peter van Zijl 1,2
1
Department of Radiology, Johns Hopkins
University, Baltimore, MD, United States,
2
F.
M. Kirby Research Center, Kennedy Krieger Institute,
Baltimore, MD, United States,
3
Department
of Medical Radiation Physics, Lund University, Lund,
Sweden,
4
Division
of Endocrinology, Diabetes, & Metabolism, Johns Hopkins
University, Baltimore, MD, United States,
5
Department
of Neurology, Johns Hopkins University, Baltimore, MD,
United States,
6
Department
of Anesthesiology and Critical Care Medicine, Johns
Hopkins University, Baltimore, MD, United States
Recent animal studies show that D-glucose is a potential
biodegradable MRI contrast agent. Here, using chemical
exchange saturation transfer (CEST) MRI, we show that it
is possible to detect dynamic changes in the human brain
at 7T during and after infusion of D-glucose. The
dynamic glucose images provide information regarding
blood arterial input function (AIF), tissue perfusion
and glucose transport. We present data from both healthy
volunteers and a brain tumor patient with anaplastic
astrocytoma showing glucose enhancement in the tumor
region. This method is promising for studying perfusion
properties of tumors and the brain.
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