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Abstract #0783

Chemical exchange sensitive Spin-lock MRI of deoxyglucose transport and metabolism in brain

Tao Jin 1 , Hunter Mehrens 1 , and Seong-Gi Kim 1,2

1 Department of Radiology, University of Pittsburgh, Pittsburgh, PA - Pennsylvania, United States, 2 Center for Neuroscience Imaging Research, Institute for Basic Science, SKKU, Suwon, Korea

Recent studies showed an increase of chemical exchange-sensitive spin-lock (CESL) MRI signal during administration of 2-deoxy-glucose (2DG). Since this CESL technique lacks molecular specificity, more studies are necessary to examine whether the signal change is caused by the transport and/or the metabolism of 2DG. The results of our in vivo study show that the CESL signal induced by administration of 2DG is strongly dependent on the injecting dose, anethesia level and brain regions. It likely contains both transport and metabolisim components and can be used as biomarker for the studied of both processes.

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