Abstract #0784
Chemical Exchange Saturation Transfer (CEST) Imaging with Double Angles and Varying Duty Cycles
Ke Li 1,2 , Hua Li 1,3 , Zhongliang Zu 1,2 , Junzhong Xu 1,2 , Jingping Xie 1,2 , Bruce M Damon 1,2 , Mark D Does 1,2 , John C Gore 1,2 , and Daniel F Gochberg 1,2
1
Institute of Imaging Sciences, Vanderbilt
University, Nashville, TN, United States,
2
Department
of Radiology and Radiological Sciences, Vanderbilt
University, Nashville, TN, United States,
3
Department
of Physics and Astronomy, Vanderbilt University,
Nashville, TN, United States
The conventional chemical exchange saturation transfer
(CEST) imaging is always confounded by the MT asymmetry
of the macromolecular proton pool and nuclear overhauser
enhancement. This work describes the development of a
new metric, named magnetization transfer ratio with
double angle and varying duty cycles (MTRdouble,vdc),
based on pulsed-CEST. A π pulse train at high duty cycle
(dc) (83.8% in this work) is used to maximize exchange
effects; while a 2π pulse train at low dc (20.95% in
this work) is used to minimize such effects. The
equivalency of this approach to an ideal continuous-wave
(CW) experiment is also demonstrated.
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