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Abstract #0785

Balanced Steady State Free Precession (bSSFP) from an effective field perspective: application to the detection of exchange (bSSFPX)

Shu Zhang 1 , Zheng Liu 2 , Robert E. Lenkinski 1,3 , and Elena Vinogradov 1,3

1 Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2 Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, 3 Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States

In this work we demonstrate that pulses of bSSFP generate an effective RF field akin to the saturation/spin-lock RF train. Thus, bSSFP and CEST/T1rho experiments are completely analogous. While in CEST the Z component of magnetization is observed, here we are focusing on the XY component. Analysis of the off-resonance frequency dependence of bSSFP profile (bSSFPX) provides information similar to CEST. We present a theoretical treatment, confirmation by simulation, and demonstrate the proof-of-principle with an image of an exchanging agent acquired using this bSSFPX approach. This method may lead to fast acquisition and quantification approaches.

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