Optimizing multislice acidoCEST MRI for assessments of extracellular pH in tumor and kidney tissues.

We have incorporated the Phase-Offset MultiPlanar (POMP) Simultaneous MultiSlice (SMS) technique into CEST-FISP MRI to create multislice acidoCEST MRI protocol that can measure extracellular pH in 3D volumes of tumor and kidney tissues. Gaussian filtering was critical for improving CEST MRI for voixelwise analysis. The pHe values in tumor and kidney tissues were measured using Bloch-McConnell fitting of CEST spectra. Although voxelwise pHe measurements have some variance, pHe analyses of tissue and sub-tissue regions have excellent precision.

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