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Abstract #0787

Cardiac CEST MRI of paraCEST labeled Cells in Cell Therapy

Ashley Pumphrey 1 , Scott Thalman 2 , Zhengshi Yang 1 , Shaojing Ye 1 , and Moriel Vandsburger 1,3

1 Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY, United States, 2 Department of Biomedical Engineering, University of Kentucky, Lexington, KY, United States, 3 Department of Physiology, University of Kentucky, Lexington, KY, United States

Using a novel cardiac chemical exchange saturation transfer (CEST) method, paraCEST labeled cells following myocardial transplantation are imaged in the mouse heart for the first time. Utilizing our recently developed cardioCEST pulse sequence we demonstrate in vivo imaging of Eu-HPDO3A labeled cells in which the contrast can essentially be "turned on" at the resonant frequency of the contrast agents exchangeable proton. With the possibility of multiple CEST contrast agents being used simultaneously, cardioCEST allows for multiplex imaging of cell tracking alongside important functional parameters of cardiac function without causing disruptive signal voids.

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