Abstract #0787
Cardiac CEST MRI of paraCEST labeled Cells in Cell Therapy
Ashley Pumphrey 1 , Scott Thalman 2 , Zhengshi Yang 1 , Shaojing Ye 1 , and Moriel Vandsburger 1,3
1
Saha Cardiovascular Research Center,
University of Kentucky, Lexington, KY, United States,
2
Department
of Biomedical Engineering, University of Kentucky,
Lexington, KY, United States,
3
Department
of Physiology, University of Kentucky, Lexington, KY,
United States
Using a novel cardiac chemical exchange saturation
transfer (CEST) method, paraCEST labeled cells following
myocardial transplantation are imaged in the mouse heart
for the first time. Utilizing our recently developed
cardioCEST pulse sequence we demonstrate in vivo imaging
of Eu-HPDO3A labeled cells in which the contrast can
essentially be "turned on" at the resonant frequency of
the contrast agents exchangeable proton. With the
possibility of multiple CEST contrast agents being used
simultaneously, cardioCEST allows for multiplex imaging
of cell tracking alongside important functional
parameters of cardiac function without causing
disruptive signal voids.
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