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Abstract #0788

Salicilyc-acid CEST PAMAM polymers for CEST imaging of delivery to brain tumors

Nikita Oskolkov 1,2 , Kannie W.Y. Chan 1,2 , Xiaolei Song 1,2 , Tao Yu 3 , Peter C.M. van Zijl 1,2 , Justin Hanes 3 , Rangaramanujam M. Kannan 3 , and Michael T. McMahon 1,2

1 The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, Maryland, United States, 2 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, United States, 3 Center for Nanomedicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States

The Poly(amido amine) (PAMAM) dendritics form a class of three dimensional, macromolecular hyperbranched globular polymers also known as dendrimers. Dendrimers have been shown to be an efficient drug delivery platform as a result of their physical and chemical properties. Their controlled size and the ease of conjugation with targeting ligands, drugs and imaging agents (i.e. MRI, X-ray, PET) for production of multifunctional nanoparticles allows the use of dendrimers as theranostic agents. In this study we have prepared a dendrimer particle with increased MRI visibility, distinguishing from contrast of dendrimer core3, which allows non-invasive visual guidance of drug delivery into brain tumors through covalent conjugation of a salicylic acid (SA) analogue which displays specific high-frequency-offset CEST contrast4 to a 4th generation carboxylate-terminated dendrimer (G3.5) and evaluated brain tumor uptake in vivo.

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