Abstract #0788
Salicilyc-acid CEST PAMAM polymers for CEST imaging of delivery to brain tumors
Nikita Oskolkov 1,2 , Kannie W.Y. Chan 1,2 , Xiaolei Song 1,2 , Tao Yu 3 , Peter C.M. van Zijl 1,2 , Justin Hanes 3 , Rangaramanujam M. Kannan 3 , and Michael T. McMahon 1,2
1
The Russell H. Morgan Department of
Radiology and Radiological Science, Johns Hopkins School
of Medicine, Baltimore, Maryland, United States,
2
F.M.
Kirby Research Center for Functional Brain Imaging,
Kennedy Krieger Institute, Baltimore, Maryland, United
States,
3
Center
for Nanomedicine, Johns Hopkins School of Medicine,
Baltimore, Maryland, United States
The Poly(amido amine) (PAMAM) dendritics form a class of
three dimensional, macromolecular hyperbranched globular
polymers also known as dendrimers. Dendrimers have been
shown to be an efficient drug delivery platform as a
result of their physical and chemical properties. Their
controlled size and the ease of conjugation with
targeting ligands, drugs and imaging agents (i.e. MRI,
X-ray, PET) for production of multifunctional
nanoparticles allows the use of dendrimers as
theranostic agents. In this study we have prepared a
dendrimer particle with increased MRI visibility,
distinguishing from contrast of dendrimer core3, which
allows non-invasive visual guidance of drug delivery
into brain tumors through covalent conjugation of a
salicylic acid (SA) analogue which displays specific
high-frequency-offset CEST contrast4 to a 4th generation
carboxylate-terminated dendrimer (G3.5) and evaluated
brain tumor uptake in vivo.
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