Abstract #0790
Validation of Quantitative Blood Flow with 3D Gradient Echo (GRE) Dynamic Contrast-enhanced Magnetic Resonance Imaging (DCE-MRI) using Blood Pool Contrast Medium in Skeletal Muscle of Swine
Stefan Hindel 1 , Anika Sauerbrey 1 , Marc Maa 2 , and Lutz Ldemann 1
1
Strahlenklinik und Poliklinik,
Universittsklinikum Essen, Essen, North
Rhine-Westphalia, Germany,
2
Evangelisches
Krankenhaus Wesel GmbH, North Rhine-Westphalia, Germany
We validated the feasibility of absolute regional
perfusion quantification by dynamic contrast-enhanced
magnetic resonance imaging (DCE-MRI) with k-space shared
sampling and a blood pool contrast agent in combination
with a two-compartment tracer kinetic model in
low-perfusion tissue. Seven female pigs were
investigated. An ultrasonic Doppler probe was attached
to the right femoral artery to determine the total flow
in the hind leg musculature. The overall flow of the
hind leg muscles, as measured by the ultrasound probe,
highly correlated with the total flow from the MRI
measurement, r = 0.89 and P=10^(-7).
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