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Abstract #0790

Validation of Quantitative Blood Flow with 3D Gradient Echo (GRE) Dynamic Contrast-enhanced Magnetic Resonance Imaging (DCE-MRI) using Blood Pool Contrast Medium in Skeletal Muscle of Swine

Stefan Hindel 1 , Anika Sauerbrey 1 , Marc Maa 2 , and Lutz Ldemann 1

1 Strahlenklinik und Poliklinik, Universittsklinikum Essen, Essen, North Rhine-Westphalia, Germany, 2 Evangelisches Krankenhaus Wesel GmbH, North Rhine-Westphalia, Germany

We validated the feasibility of absolute regional perfusion quantification by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with k-space shared sampling and a blood pool contrast agent in combination with a two-compartment tracer kinetic model in low-perfusion tissue. Seven female pigs were investigated. An ultrasonic Doppler probe was attached to the right femoral artery to determine the total flow in the hind leg musculature. The overall flow of the hind leg muscles, as measured by the ultrasound probe, highly correlated with the total flow from the MRI measurement, r = 0.89 and P=10^(-7).

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