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Abstract #0791

Effects of temporal resolution on DCE-MRI parameter estimation: In-vivo repeatability analysis of lung tumors using retroactively adjustable KWIC reconstruction

Xia Zhao 1,2 , Yiqun Xue 1,2 , Mark Rosen 2 , Hyunseon Kang 3 , Ramesh Rengan 4 , and Heekwon Song 1,2

1 Laboratory for Structural NMR Imaging, University of Pennsylvania, Philadelphia, PA, United States, 2 Department of Radiology, Hospital of University of Pennsylvania, Philadelphia, PA, United States, 3 MD Anderson Cancer Center, University of Texas, Houston, TX, United States, 4 Department of Radiation Oncology, University of Washington School of Medicine, Seattle, WA, United States

In this work, we investigate the effects of temporal resolution on measured tumor perfusion parameters and also its effects on repeatability on a test-retest dataset acquired in vivo in patients with lung tumor. We utilize interleaved radial acquisition (golden angle view angle increment) along with KWIC reconstruction which enables different temporal resolutions to be chosen retrospectively during image reconstruction. Our results demonstrate that repeatability is relatively constant up to about 13 sec frame rate (CV ~ 11%). In agreement with previous simulation studies, K trans is increasingly underestimated at reduced temporal resolutions.

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