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Abstract #0792

Measuring blood-brain-barrier permeability using Diffusion-Weighted Arterial Spin Labeling (DW-ASL): Corroboration with Ktrans and Evans blue measurements

Yash Vardhan Tiwari 1,2 , Qiang Shen 1 , Zhao Jiang 1 , Wei Li 1 , Justin Long 1,2 , Chenling Fang 1,2 , and Timothy Duong 1

1 Research Imaging Institute, UT Health Science Center, San Antonio, Texas, United States, 2 Biomedical Engineering, UT, San Antonio, Texas, United States

Blood-brain-barrier (BBB) dysfunction has been implicated in a number of neurological disorders, such as multiple sclerosis, stroke and cancer. BBB integrity can be assessed by measuring the water exchange rate across the BBB (Kw) defined as PS/Vc where PS is permeability surface area product and Vc is capillary distribution volume of water. Diffusion-weighted arterial spin labeling (DW-ASL) was recently proposed to measure Kw without using an exogenous contrast agent in humans1. However, this approach has not been validated. The goal of this study was to compare Kw measurements (DW-ASL) with Ktrans (DCE MRI) and histological staining (Evans blue) in the same rats. Measurements were also made before and after mannitol administration to break the BBB.

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