Abstract #0792
Measuring blood-brain-barrier permeability using Diffusion-Weighted Arterial Spin Labeling (DW-ASL): Corroboration with Ktrans and Evans blue measurements
Yash Vardhan Tiwari 1,2 , Qiang Shen 1 , Zhao Jiang 1 , Wei Li 1 , Justin Long 1,2 , Chenling Fang 1,2 , and Timothy Duong 1
1
Research Imaging Institute, UT Health
Science Center, San Antonio, Texas, United States,
2
Biomedical
Engineering, UT, San Antonio, Texas, United States
Blood-brain-barrier (BBB) dysfunction has been
implicated in a number of neurological disorders, such
as multiple sclerosis, stroke and cancer. BBB integrity
can be assessed by measuring the water exchange rate
across the BBB (Kw) defined as PS/Vc where PS is
permeability surface area product and Vc is capillary
distribution volume of water. Diffusion-weighted
arterial spin labeling (DW-ASL) was recently proposed to
measure Kw without using an exogenous contrast agent in
humans1. However, this approach has not been validated.
The goal of this study was to compare Kw measurements
(DW-ASL) with Ktrans (DCE MRI) and histological staining
(Evans blue) in the same rats. Measurements were also
made before and after mannitol administration to break
the BBB.
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