Intra and Inter-subject Reproducibility of Arterial Transit Time
Tracy Ssali 1,2 , Udunna C Anazodo 1,2 , Mahsa Shokouhi 1 , Bradley J MacIntosh 3 , and Keith St Lawrence 1,2
Laswon Health Research Institute, London,
of Western Ontario, London, Ontario, Canada,
Health Sciences Centre, Toronto, Ontario, Canada
It is known that knowledge of the arterial transit time
(ATT) is essential for CBF quantification; however,
typically ATT imaging is time consuming. The aim of this
study was to assess intra- and inter-subject
reproducibility of ATT. Across sessions and subjects,
the voxel-wise GM CV were 6.0% and 10.0%, respectively.
Variance in mean GM ATT inter-subject was 44.7ms
(CV=5.4%) and 5.9ms (CV=0.7%) inter-session. The low
variance demonstrates the stability of ATT measurements
in young healthy individuals. Next, would be to assess
reproducibility of ATT in older subject groups and
patient populations with cerebral pathology where
perfusion characteristics have greater variability.
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