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Abstract #0799

Localized Detection of Fasting-Induced Changes in Lactate Metabolism By Hyperpolarized 13 C MRSI

Cornelius von Morze 1 , Gene-Yuan Chang 2 , Peder E Larson 1 , Hong Shang 1 , Robert A Bok 1 , Jason C Crane 1 , Marram P Olson 1 , C.T. Tan 3 , Sarah J Nelson 1 , John Kurhanewicz 1 , David Pearce 2 , and Daniel B Vigneron 1

1 Department of Radiology & Biomedical Imaging, UCSF, San Francisco, California, United States, 2 Department of Medicine, UCSF, San Francisco, California, United States, 3 ISOTEC, Sigma-Aldrich, Miamisburg, Ohio, United States

MRSI of hyperpolarized (HP) 13 C-labeled compounds is a powerful new approach for localized non-invasive studies of tissue metabolism in vivo. The purpose of this study was to characterize tissue-specific alterations in the metabolism of HP gluconeogenic precursors 13 C-lactate and 13 C-pyruvate by rat liver and kidneys in response to fasting. Seven rats were studied by 13C MRSI of both HP 13 C-lactate and 13 C-pyruvate in both normal fed and 24h fasting states. Significant metabolic modulations associated with fasting were identified in the localized metabolite data resulting from these spectroscopic imaging experiments.

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