Abstract #0820
High resolution MR elastography reveals disseminated white matter degradation of brain tissue integrity in clinically isolated syndrome
Andreas Fehlner 1 , Kaspar-Josche Streitberger 1,2 , Friedemann Paul 3,4 , Jens Wrfel 3,5 , Jrgen Braun 6 , and Ingolf Sack 1
1
Department of Radiology, Charit -
Universittsmedizin Berlin, Berlin, Germany,
2
Department
of Neurology with experimental Neurology, Charit -
Universittsmedizin Berlin, Berlin, Germany,
3
NeuroCure
Clinical Research Center, Charit - Universittsmedizin
Berlin, Berlin, Germany,
4
Clinical
and Experimental Multiple Sclerosis Research Center,
Department of Neurology, Charit - Universittsmedizin
Berlin, Berlin, Germany,
5
Institute
of Neuroradiology, Universittsmedizin Gttingen,
Gttingen, Germany,
6
Institute
of Medical Informatics, Charit - Universittsmedizin
Berlin, Berlin, Germany
High resolution multifrequency MR elastography (MMRE)
was applied to patients with clinical isolated syndrome
(CIS) in order to test if white matter viscoelasticity
is significantly affected by a single neurological
episode of inflammation or demyelination. On average, we
observed a significant reduction of the magnitude of the
complex shear modulus (~11%, p = 0.001) in 17 CIS
patients compared to healthy controls. This study
complements previous findings on the gradual mechanical
degradation of brain tissue associated with multiple
sclerosis and raises the prospect of using MMRE as an
early marker of neuroinflammation and demyelination.
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