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Abstract #0820

High resolution MR elastography reveals disseminated white matter degradation of brain tissue integrity in clinically isolated syndrome

Andreas Fehlner 1 , Kaspar-Josche Streitberger 1,2 , Friedemann Paul 3,4 , Jens Wrfel 3,5 , Jrgen Braun 6 , and Ingolf Sack 1

1 Department of Radiology, Charit - Universittsmedizin Berlin, Berlin, Germany, 2 Department of Neurology with experimental Neurology, Charit - Universittsmedizin Berlin, Berlin, Germany, 3 NeuroCure Clinical Research Center, Charit - Universittsmedizin Berlin, Berlin, Germany, 4 Clinical and Experimental Multiple Sclerosis Research Center, Department of Neurology, Charit - Universittsmedizin Berlin, Berlin, Germany, 5 Institute of Neuroradiology, Universittsmedizin Gttingen, Gttingen, Germany, 6 Institute of Medical Informatics, Charit - Universittsmedizin Berlin, Berlin, Germany

High resolution multifrequency MR elastography (MMRE) was applied to patients with clinical isolated syndrome (CIS) in order to test if white matter viscoelasticity is significantly affected by a single neurological episode of inflammation or demyelination. On average, we observed a significant reduction of the magnitude of the complex shear modulus (~11%, p = 0.001) in 17 CIS patients compared to healthy controls. This study complements previous findings on the gradual mechanical degradation of brain tissue associated with multiple sclerosis and raises the prospect of using MMRE as an early marker of neuroinflammation and demyelination.

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