Abstract #0821
Ultra-high field MRI longitudinal MS lesion study
Bryson Dietz 1 , David A Rudko 2 , Marcelo Kremenchutzky 3 , and Ravi S Menon 1,4
1
Centre for Functional and Metabolic Mapping,
Robarts Research Institute, Western University, London,
ON, Canada,
2
Montreal
Neurological Institute, McGill University, Montreal, QC,
Canada,
3
London
Health Sciences Centre, London, ON, Canada,
4
Department
of Medical Biophysics, Western University, London, ON,
Canada
Longitudinal ultra-high field MR imaging was conducted
on 16 relapse remitting multiple sclerosis (RRMS)
patients, along with 16 age-matched controls. Lesions
were investigated temporally using quantitative
susceptibility mapping (QSM) and R2* quantitative
imaging. For ringed lesions, we upsampled the image and
separated the ring from the inner lesion core, to
evaluate each separately. We found that lesion ring and
inner core behave similarly over time, which indicates
they both respond similarly to biological changes
occurring within the tissue. We found R2* to slowly
decrease as lesions form, whereas QSM has a sudden jump
in susceptibility.
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