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Abstract #0821

Ultra-high field MRI longitudinal MS lesion study

Bryson Dietz 1 , David A Rudko 2 , Marcelo Kremenchutzky 3 , and Ravi S Menon 1,4

1 Centre for Functional and Metabolic Mapping, Robarts Research Institute, Western University, London, ON, Canada, 2 Montreal Neurological Institute, McGill University, Montreal, QC, Canada, 3 London Health Sciences Centre, London, ON, Canada, 4 Department of Medical Biophysics, Western University, London, ON, Canada

Longitudinal ultra-high field MR imaging was conducted on 16 relapse remitting multiple sclerosis (RRMS) patients, along with 16 age-matched controls. Lesions were investigated temporally using quantitative susceptibility mapping (QSM) and R2* quantitative imaging. For ringed lesions, we upsampled the image and separated the ring from the inner lesion core, to evaluate each separately. We found that lesion ring and inner core behave similarly over time, which indicates they both respond similarly to biological changes occurring within the tissue. We found R2* to slowly decrease as lesions form, whereas QSM has a sudden jump in susceptibility.

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