Abstract #0822
Beyond focal cortical lesions in multiple sclerosis: an in vivo quantitative and spatial imaging study at 7 T
Cline Louapre 1,2 , Sindhuja T Govindarajan 1 , Costanza Giann 1,2 , Jacob A Sloane 3 , RP Kinkel 4 , and Caterina Mainero 1,2
1
AA. Martinos Center for Biomedical Imaging,
Charlestown, MA, United States,
2
Harvard
Medical School, Boston, MA, United States,
3
Beth
Israel Deaconess Medical Center, Boston, MA, United
States,
4
University
of California San Diego, San Diego, CA, United States
We investigate 7 T T
2
* relaxation rates in
the cortex of subjects with multiple sclerosis (MS) to
determine: 1) quantitative T
2
* changes in and
beyond visible focal cortical lesions (CL), 2) the
spatial distribution of focal MS CL across the cortex,
3) the impact of focal CL on the surrounding
peri-lesional cortex. MS focal CL exhibit longer T
2
*
than healthy cortex. Quantitative T
2
* changes
extend beyond visible CL in progressive MS. Cortical
lesions, however, have the same impact on surrounding
peri-lesional cortex across disease stages.
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