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Abstract #0822

Beyond focal cortical lesions in multiple sclerosis: an in vivo quantitative and spatial imaging study at 7 T

Cline Louapre 1,2 , Sindhuja T Govindarajan 1 , Costanza Giann 1,2 , Jacob A Sloane 3 , RP Kinkel 4 , and Caterina Mainero 1,2

1 AA. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2 Harvard Medical School, Boston, MA, United States, 3 Beth Israel Deaconess Medical Center, Boston, MA, United States, 4 University of California San Diego, San Diego, CA, United States

We investigate 7 T T 2 * relaxation rates in the cortex of subjects with multiple sclerosis (MS) to determine: 1) quantitative T 2 * changes in and beyond visible focal cortical lesions (CL), 2) the spatial distribution of focal MS CL across the cortex, 3) the impact of focal CL on the surrounding peri-lesional cortex. MS focal CL exhibit longer T 2 * than healthy cortex. Quantitative T 2 * changes extend beyond visible CL in progressive MS. Cortical lesions, however, have the same impact on surrounding peri-lesional cortex across disease stages.

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