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Abstract #0823

Multivariate combination of magnetization transfer ratio and quantitative T 2 * to detect subpial demyelination in multiple sclerosis

Gabriel Mangeat 1,2 , Sindhuja Tirumalai Govindarajan 2 , Revere Philip Kinkel 3 , Caterina Mainero 2,4 , and Julien Cohen-Adad 1,5

1 Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, Qc, Canada, 2 Martinos Center for Biomedical Imaging, MGH, Charlestown, MA, United States, 3 Clinical Neurosciences, University of California San Diego, La Jolla, CA, United States, 4 Harvard Medical School, Boston, MA, United States, 5 Functional Neuroimaging Unit, CRIUGM, Universit de Montral, Montreal, Qc, Canada

We introduce a multivariate statistical framework for combining cortical sampling of MTR and T 2 * to gain specificity for mapping cortical myelin content. (i) We sampled cortical MTR and T 2 * from Freesurfer segmentation. (ii) we normalized MTR and T 2 * maps and corrected them for partial volume effect and B0 orientation. (iii) we extracted the shared myelin information using a spatial independent component analysis. We demonstrate the benefits of this framework for separating healthy controls from subject with multiple sclerosis on the basis of cortical pathology.

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