Abstract #0823
Multivariate combination of magnetization transfer ratio and quantitative T 2 * to detect subpial demyelination in multiple sclerosis
Gabriel Mangeat 1,2 , Sindhuja Tirumalai Govindarajan 2 , Revere Philip Kinkel 3 , Caterina Mainero 2,4 , and Julien Cohen-Adad 1,5
1
Institute of Biomedical Engineering,
Polytechnique Montreal, Montreal, Qc, Canada,
2
Martinos
Center for Biomedical Imaging, MGH, Charlestown, MA,
United States,
3
Clinical
Neurosciences, University of California San Diego, La
Jolla, CA, United States,
4
Harvard
Medical School, Boston, MA, United States,
5
Functional
Neuroimaging Unit, CRIUGM, Universit de Montral,
Montreal, Qc, Canada
We introduce a multivariate statistical framework for
combining cortical sampling of MTR and T
2
* to
gain specificity for mapping cortical myelin content.
(i) We sampled cortical MTR and T
2
* from
Freesurfer
segmentation.
(ii) we normalized MTR and T
2
* maps and
corrected them for partial volume effect and B0
orientation. (iii) we extracted the shared myelin
information using a spatial independent component
analysis. We demonstrate the benefits of this framework
for separating healthy controls from subject with
multiple sclerosis on the basis of cortical pathology.
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