Multivariate combination of magnetization transfer ratio and quantitative T 2 * to detect subpial demyelination in multiple sclerosis
Gabriel Mangeat 1,2 , Sindhuja Tirumalai Govindarajan 2 , Revere Philip Kinkel 3 , Caterina Mainero 2,4 , and Julien Cohen-Adad 1,5
Institute of Biomedical Engineering,
Polytechnique Montreal, Montreal, Qc, Canada,
Center for Biomedical Imaging, MGH, Charlestown, MA,
Neurosciences, University of California San Diego, La
Jolla, CA, United States,
Medical School, Boston, MA, United States,
Neuroimaging Unit, CRIUGM, Universit de Montral,
Montreal, Qc, Canada
We introduce a multivariate statistical framework for
combining cortical sampling of MTR and T
gain specificity for mapping cortical myelin content.
(i) We sampled cortical MTR and T
(ii) we normalized MTR and T
* maps and
corrected them for partial volume effect and B0
orientation. (iii) we extracted the shared myelin
information using a spatial independent component
analysis. We demonstrate the benefits of this framework
for separating healthy controls from subject with
multiple sclerosis on the basis of cortical pathology.
This abstract and the presentation materials are available to members only;
a login is required.