Abstract #0825
Voxel-based analysis of subcortical grey matter using transverse relaxation and quantitative susceptibility mapping: application to multiple sclerosis
Dana Cobzas 1 , Hongfu Sun 1 , Andrew J. Walsh 1 , R. Marc Lebel 1 , Gregg Blevins 2 , and Alan H. Wilman 1
1
Biomedical Engineering, University of
Alberta, Edmonton, Alberta, Canada,
2
Neurology,
University of Alberta, Edmonton, Alberta, Canada
Quantitative Susceptibility Mapping (QSM) and R2*
mapping studies of subcortical grey matter have
generally analyzed large regions-of-interest that do not
supply precise location of iron accumulation. Large
regions have been used partly due to the difficulty of
accurate segmentation of deep grey matter. Here we
develop a focused deep grey nuclei atlas using combined
QSM and T1-weighted images and investigate its precision
and reliability for voxel-based subcortical grey matter
analysis using R2* and QSM. We then apply our method to
multiple sclerosis to determine local effects of iron
accumulation in subcortical grey matter nuclei.
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