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Abstract #0825

Voxel-based analysis of subcortical grey matter using transverse relaxation and quantitative susceptibility mapping: application to multiple sclerosis

Dana Cobzas 1 , Hongfu Sun 1 , Andrew J. Walsh 1 , R. Marc Lebel 1 , Gregg Blevins 2 , and Alan H. Wilman 1

1 Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada, 2 Neurology, University of Alberta, Edmonton, Alberta, Canada

Quantitative Susceptibility Mapping (QSM) and R2* mapping studies of subcortical grey matter have generally analyzed large regions-of-interest that do not supply precise location of iron accumulation. Large regions have been used partly due to the difficulty of accurate segmentation of deep grey matter. Here we develop a focused deep grey nuclei atlas using combined QSM and T1-weighted images and investigate its precision and reliability for voxel-based subcortical grey matter analysis using R2* and QSM. We then apply our method to multiple sclerosis to determine local effects of iron accumulation in subcortical grey matter nuclei.

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