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Abstract #0826

Regional white matter abnormalities and cognitive impairment in MS: a multicenter TBSS study

Elisabetta Pagani 1 , Maria A. Rocca 1,2 , Alvino Bisecco 1 , Olga Ciccarelli 3 , Christian Enzinger 4 , Antonio Gallo 5 , Hugo Vrenken 6 , Maria Laura Stromillo 7 , Tarek A. Yousry 3 , Franz Fazekas 4 , Gioacchino Tedeschi 5 , Frederik Barkhof 6 , Nicola De Stefano 7 , Massimo Filippi 1,2 , and the MAGNIMS Network 8

1 Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, MI, Italy, 2 Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, MI, Italy, 3 UCLH NHS Foundation Trust, National Hospital for Neurology and Neurosurgery, London, UK, United Kingdom, 4 Department of Neurology, Medical University of Graz, Graz, A, Austria, 5 MRI Center SUN-FISM", Second University of Naples, Naples, NA, Italy, 6 Department of Radiology, VU University Medical Centre, Amsterdam, Netherlands, Netherlands, 7 Department of Neurological and Behavioral Sciences, University of Siena, Siena, SI, Italy, 8 EU, EU, Italy

Single center studies have shown an association between disrupted white matter architectural integrity and clinical manifestations, including cognitive impairment, in multiple sclerosis (MS). In this study, we applied voxel wise analysis of diffusion tensor derived metrics in data obtained in a multi-center setting to assess the spatial distribution of white matter damage in MS and its relationship with cognitive impairment. We found significant differences comparing cognitive impaired with cognitive preserved patients and correlations with cognitive tests. We concluded that this approach is feasible in a multi-center setting and it contributes to better characterize disease related cognitive manifestations.

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