Abstract #0826
Regional white matter abnormalities and cognitive impairment in MS: a multicenter TBSS study
Elisabetta Pagani 1 , Maria A. Rocca 1,2 , Alvino Bisecco 1 , Olga Ciccarelli 3 , Christian Enzinger 4 , Antonio Gallo 5 , Hugo Vrenken 6 , Maria Laura Stromillo 7 , Tarek A. Yousry 3 , Franz Fazekas 4 , Gioacchino Tedeschi 5 , Frederik Barkhof 6 , Nicola De Stefano 7 , Massimo Filippi 1,2 , and the MAGNIMS Network 8
1
Neuroimaging Research Unit, Institute of
Experimental Neurology, Division of Neuroscience, San
Raffaele Scientific Institute, Vita-Salute San Raffaele
University, Milan, MI, Italy,
2
Department
of Neurology, San Raffaele Scientific Institute,
Vita-Salute San Raffaele University, Milan, MI, Italy,
3
UCLH
NHS Foundation Trust, National Hospital for Neurology
and Neurosurgery, London, UK, United Kingdom,
4
Department
of Neurology, Medical University of Graz, Graz, A,
Austria,
5
MRI
Center SUN-FISM", Second University of Naples, Naples,
NA, Italy,
6
Department
of Radiology, VU University Medical Centre, Amsterdam,
Netherlands, Netherlands,
7
Department
of Neurological and Behavioral Sciences, University of
Siena, Siena, SI, Italy,
8
EU,
EU, Italy
Single center studies have shown an association between
disrupted white matter architectural integrity and
clinical manifestations, including cognitive impairment,
in multiple sclerosis (MS). In this study, we applied
voxel wise analysis of diffusion tensor derived metrics
in data obtained in a multi-center setting to assess the
spatial distribution of white matter damage in MS and
its relationship with cognitive impairment. We found
significant differences comparing cognitive impaired
with cognitive preserved patients and correlations with
cognitive tests. We concluded that this approach is
feasible in a multi-center setting and it contributes to
better characterize disease related cognitive
manifestations.
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