Abstract #0827
Cognitive status of multiple sclerosis patients is associated with neocortical neuronal injury: A voxel-based sodium MRI study
Adil Maarouf 1,2 , Bertrand Audoin 1 , Anthony Faivre 1 , Francoise Reuter 1 , Fanelly Pariollaud 1 , Audrey Rico 1 , Elisabeth Soulier 1 , Sylviane Confort-Gouny 1 , Maxime Guye 1 , Lothar Schad 3 , Jean Pelletier 1 , Jean-Philippe Ranjeva 1 , and Wafaa Zaaraoui 1
1
CRMBM UMR CNRS 7339 Aix-Marseille
Universit, Marseille, France,
2
Facult
de Mdecine, Universit de Reims Champagne-Ardenne,
Reims, France,
3
Computer Assisted Clinical
Medicine, Heidelberg University, Mannheim, Germany
This study aimed to assess brain sodium accumulation in
cognitive MS. Fifty-eight patients and 31 controls were
included in a sodium MRI study performed at 3T. Total
sodium concentration (TSC) was increased in cognitive MS
patients compared to non-cognitive MS patients and
controls. These sodium accumulations were located in the
cingulate cortex, precuneus, temporal and prefrontal
cortices, independently of atrophy. In cognitive MS,
sodium accumulation, which is an indicator of neuronal
injury, affects the neocortex (involved in higher
functions). Sodium MRI is able to depict neuronal
injury, very early in the disease, before the occurrence
of atrophy.
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