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Abstract #0827

Cognitive status of multiple sclerosis patients is associated with neocortical neuronal injury: A voxel-based sodium MRI study

Adil Maarouf 1,2 , Bertrand Audoin 1 , Anthony Faivre 1 , Francoise Reuter 1 , Fanelly Pariollaud 1 , Audrey Rico 1 , Elisabeth Soulier 1 , Sylviane Confort-Gouny 1 , Maxime Guye 1 , Lothar Schad 3 , Jean Pelletier 1 , Jean-Philippe Ranjeva 1 , and Wafaa Zaaraoui 1

1 CRMBM UMR CNRS 7339 Aix-Marseille Universit, Marseille, France, 2 Facult de Mdecine, Universit de Reims Champagne-Ardenne, Reims, France, 3 Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany

This study aimed to assess brain sodium accumulation in cognitive MS. Fifty-eight patients and 31 controls were included in a sodium MRI study performed at 3T. Total sodium concentration (TSC) was increased in cognitive MS patients compared to non-cognitive MS patients and controls. These sodium accumulations were located in the cingulate cortex, precuneus, temporal and prefrontal cortices, independently of atrophy. In cognitive MS, sodium accumulation, which is an indicator of neuronal injury, affects the neocortex (involved in higher functions). Sodium MRI is able to depict neuronal injury, very early in the disease, before the occurrence of atrophy.

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