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Abstract #0834

Multifunctional Liposome for Non-small Cell Lung Cancer Targeting and Theranostic MRI

Ren Lili 1 , Shizhen Chen 1 , Haidong Li 1 , Zhiying Zhang 1 , Jianping Zhong 1 , and Xin Zhou 1

1 National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Wuhan, Hubei, China

A multifunctional liposome, which contained Gd-DOTA (MRI probe), paclitexal (PTX) and c(RGDyk) (targeting peptide), was prepared. This nanoparticle could utilize the insolubility of PTX, reduce the side effect of FDA-approved formulation of PTX-Cre (Taxol), and improve the drug delivery efficiency to tumor.

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