Abstract #0836
Differing Contributions of Whole Brain Fractional Anisotropy, Axon Density and Axon Dispersion to Neurodevelopmental Outcomes of Children Born Very Preterm
Claire E Kelly 1 , Deanne K Thompson 1,2 , Jian Chen 1,3 , Alexander Leemans 4 , Christopher L Adamson 1 , Terrie E Inder 5 , Jeanie LY Cheong 1,6 , Lex W Doyle 1,6 , and Peter J Anderson 1,7
1
Murdoch Childrens Research Institute,
Melbourne, VIC, Australia,
2
Florey
Institute of Neuroscience and Mental Health, Melbourne,
VIC, Australia,
3
Monash
University, Melbourne, VIC, Australia,
4
Image
Sciences Institute, University Medical Center Utrecht,
Utrecht, Netherlands,
5
Brigham
and Womens Hospital, Boston, MA, United States,
6
Royal
Womens Hospital, Melbourne, VIC, Australia,
7
University
of Melbourne, Melbourne, VIC, Australia
Children born very preterm (VPT; <32 weeks gestation)
are at risk of neurodevelopmental delays. We aimed to
determine whether whole brain Diffusion Tensor Imaging
(DTI) and Neurite Orientation Dispersion and Density
Imaging (NODDI) values are associated with
neurodevelopment in 145 VPT 7-year-olds. Decreasing
fractional anisotropy in widespread fiber tracts
correlated with poorer cognitive, motor, academic and
behavioral/emotional outcomes. In many of the same
tracts, increasing axon dispersion correlated with
poorer motor outcome, while decreasing axon density
correlated with poorer behavioural/emotional outcome.
DTI combined with NODDI enables more specific
identification of the microstructural factors
contributing to neurodevelopmental outcomes in VPT
children.
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