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Abstract #0838

Does using a 16-element receive-array improve whole-liver 31 P metabolite ratio quantification at 7T?

Lucian A. B. Purvis 1 , William T. Clarke 1 , Michael Pavlides 1 , Stefan Neubauer 1 , Matthew D. Robson 1 , and Christopher T. Rodgers 1

1 Department of Cardiovascular Medicine, University of Oxford, Oxford, Oxfordshire, United Kingdom

Using a 16-element receive array at 7T permitted precise quantification of 31 P metabolite ratios from the whole liver, in a study on 5 normal volunteers. A 3D UTE-CSI sequence gave an average of 27 voxels (each 6.3mL nominal volume) of high quality data for each subject. The inter-subject mean and SD of the metabolite ratios (averaged over all voxels) were then calculated: 36.4 6.94 for PME/PDE, 44.4 3.93 for GPC/Total Ester and 12.6 3.58 for PE/Total Ester. This preliminary work will inform the design of future clinical studies of diseases such as non-alcoholic fatty liver disease.

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