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Abstract #0839

Combined Gadoxetic Acid and Gadofosveset enhanced Liver MRI: Detection and Characterization of Focal Liver Lesions

Peter Bannas 1,2 , Candice A Bookwalter 1 , Tim Ziemlewicz 1 , Utaroh Motosugi 1 , Richard Bruce 1 , Theodora A Potretzke 1 , and Scott B Reeder 1,3

1 Radiology, University of Wisconsin-Madison, Madison, WI, United States, 2 Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Hamburg, Germany, 3 Medical Physics, University of Wisconsin-Madison, WI, United States

On gadoxetic acid enhanced hepatobiliary-phase MRI it can be challenging to detect small and/or perivascular focal liver metastases. Moreover, both metastases and benign cavernous hemangiomas appear hypointense and may be difficult to distinguish from one another. In this study we compared hepatobiliary phase MRI for detection and characterization of liver lesions by using an intravascular gadolinium based contrast agent, gadofosveset trisodium, in addition to gadoxetic acid in 78 patients with suspected metastases or hemangiomas. Our results revealed that combined gadoxetic acid and gadofosveset enhanced liver MRI improves liver lesion detection and characterization when compared to gadoxetic acid alone.

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