Combined Gadoxetic Acid and Gadofosveset enhanced Liver MRI: Detection and Characterization of Focal Liver Lesions
Peter Bannas 1,2 , Candice A Bookwalter 1 , Tim Ziemlewicz 1 , Utaroh Motosugi 1 , Richard Bruce 1 , Theodora A Potretzke 1 , and Scott B Reeder 1,3
Radiology, University of Wisconsin-Madison,
Madison, WI, United States,
University Medical Center Hamburg-Eppendorf, Hamburg,
Physics, University of Wisconsin-Madison, WI, United
On gadoxetic acid enhanced hepatobiliary-phase MRI it
can be challenging to detect small and/or perivascular
focal liver metastases. Moreover, both metastases and
benign cavernous hemangiomas appear hypointense and may
be difficult to distinguish from one another. In this
study we compared hepatobiliary phase MRI for detection
and characterization of liver lesions by using an
intravascular gadolinium based contrast agent,
gadofosveset trisodium, in addition to gadoxetic acid in
78 patients with suspected metastases or hemangiomas.
Our results revealed that combined gadoxetic acid and
gadofosveset enhanced liver MRI improves liver lesion
detection and characterization when compared to
gadoxetic acid alone.
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