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Abstract #0840

Adipose Tissue Hydration as a Potential Non-invasive Marker for Adipose Tissue Hypertrophy

Navin Michael 1 , Suresh Anand Sadananthan 1 , Jadegoud Yaligar 2 , Swee Shean Lee 2 , Melvin Khee-Shing Leow 1,3 , Chin Meng Khoo 4 , Eric Yin Hao Khoo 4 , Kavita Venkataraman 5 , Yung Seng Lee 1,6 , Yap Seng Chong 1,7 , Peter D. Gluckman 1 , E. Shyong Tai 4 , and S. Sendhil Velan 2,8

1 Singapore Institute for Clinical Sciences, A*STAR, Singapore, 2 Singapore BioImaging Consortium, A*STAR, Singapore, 3 Department of Endocrinology, Tan Tock Seng Hospital, Singapore, 4 Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 5 Saw Swee Hock School of Public Health, National University of Singapore, Singapore, 6 Department of Paediatrics, Yong Loo Lin School of Medicine, Singapore, 7 Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, Singapore, 8 Clinical Imaging Research Centre, A*STAR, Singapore

The ability to measure adipose hypertrophy in vivo is relevant to better understand the pathophysiology involved in type 2 diabetes. Traditionally, adipose tissue hypertrophy has been assessed directly by histological examination of adipose tissue explants which is invasive and inconvenient to carry out in large cohort studies. The current work investigates the use of adipose tissue hydration, as measured using 1 H MRS based hydrolipidic ratio, as a noninvasive marker of adipose tissue hypertrophy, and its association with serum metabolic parameters, insulin sensitivity, BMI, adipose depot volumes and ectopic fat infiltration in liver and skeletal muscle.

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