Abstract #0841
Modelling skull dynamics during brain magnetic resonance elastography to evaluate wave delivery strategies
Deirdre M McGrath 1,2 , Alejandro F Frangi 1 , Iain D Wilkinson 2 , and Zeike A Taylor 1
1
CISTIB, Center for Computational Imaging &
Simulation Technologies in Biomedicine, University of
Sheffield, Sheffield, South Yorkshire, United Kingdom,
2
Academic
Radiology, University of Sheffield, Sheffield, South
Yorkshire, United Kingdom
Magnetic resonance elastography (MRE) is currently being
explored as a biomarker of neurodegenerative disease
including dementia. A difficulty for this process of
evaluation is that the measures of biomechanical
properties obtained for healthy brain using MRE have
varied widely. However the methodology has not been
consistent between studies, such as wave frequency and
the means of wave delivery. In this work an initial
evaluation of has been made of a method to simulate
skull vibration dynamics during MRE, to compare the
impact of delivering the waves from different positions
on the skull.
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