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Abstract #0841

Modelling skull dynamics during brain magnetic resonance elastography to evaluate wave delivery strategies

Deirdre M McGrath 1,2 , Alejandro F Frangi 1 , Iain D Wilkinson 2 , and Zeike A Taylor 1

1 CISTIB, Center for Computational Imaging & Simulation Technologies in Biomedicine, University of Sheffield, Sheffield, South Yorkshire, United Kingdom, 2 Academic Radiology, University of Sheffield, Sheffield, South Yorkshire, United Kingdom

Magnetic resonance elastography (MRE) is currently being explored as a biomarker of neurodegenerative disease including dementia. A difficulty for this process of evaluation is that the measures of biomechanical properties obtained for healthy brain using MRE have varied widely. However the methodology has not been consistent between studies, such as wave frequency and the means of wave delivery. In this work an initial evaluation of has been made of a method to simulate skull vibration dynamics during MRE, to compare the impact of delivering the waves from different positions on the skull.

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