Abstract #0842
Isocaloric Fructose Restriction for 10 Days Reduces MR-Measured Liver, Pancreatic and Visceral Fat in High Sugar-consuming, Obese Children
Susan M Noworolski 1 , Kathleen Mulligan 2 , Natalie Korn 1 , Molly Gibson 1 , Viva W Tai 2,3 , Michael Wen 2 , Ayca Erkin-Cakmak 4 , Alejandro Gugliucci 5 , Robert H Lustig 4 , and Jean-Marc Schwarz 6
1
Radiology & Biomedical Imaging, University
of California, San Francisco, California, United States,
2
Medicine,
University of California, San Francisco, California,
United States,
3
CTSI-CRS,
University of California, San Francisco, California,
United States,
4
Pediatrics,
University of California, San Francisco, California,
United States,
5
Research,
Touro University College of Osteopathic Medicine,
Vallejo, California, United States,
6
Basic
Science, Touro University College of Osteopathic
Medicine, Vallejo, California, United States
Thirty-six obese African American and Latino high-sugar
consuming children underwent a 10-day isocaloric,
fructose/sugar-restricted diet. Liver, pancreatic,
visceral fat (VAT), and subcutaneous fat (SAT) were
measured at baseline and 10 days later using MRS and
Dixon-type imaging at 3T. The liver fat fraction
decreased 29.5% 23% (p<0.001). Pancreatic fat fraction
was lower in 74% (20/27) participants (p<0.05) with
varied amounts of decrease. VAT decreased 6.9% 14%
(p<0.006) while SAT did not change significantly.
Subjects lost 1.1 1.2% of body weight during the
study. Decreases in MR-measured fat remained significant
after adjustment for this minor weight loss.
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